INX-08189 is (E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl) prop-2-en-1-one is clinical trial drug candidate for hepatitis C virus. In this study, we are presenting possible binding mechanism of said candidate by docking simulation. The study divulge that, INX-08189 bind with viral protein by arene-arene, arene-cation and hydrophobic interactions. It is noted that, INX-8189 acquire different conformation in receptor pocket by exhibiting different enantiomeric forms.
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